INTRODUCTION AND OBJECTIVES: The increasing amount of economic evaluations in health technologies published during the last decades have generated the concern about their methodological features. The aim of this study is, firstly, to explore methodological reviews and to detect their main research topics and, secondly, to appraise their usefulness for economic evaluation practice.    METHODS: We performed systematic searches in electronic databases (Scopus, Medline and Pubmed) of methodological reviews published in English, period 1990-  2010. We selected those articles whose main purpose was to review and assess the applied methodology. Then we classified data according to study objectives, period of the review, number of reviewed studies,  methodological items assessed and their main conclusions. Additionally, we checked how generalizability issues were considered in the reviews. RESULTS:  A total of 58 methodological reviews were identified, 42 were published during the period 1990 - 2001 and 16 during 2002-10. Items most frequently assessed (by 70% of the reviews) were: perspective, uncertainty and discounting. The type of intervention and disease, funding sources, country in which the evaluation took place, type of journal and author’s characteristics were also described in the literature. Generalizability issues were only checked  in 14 studies, mainly by those published after 2000. CONCLUSIONS: there is an increasing activity of reviewing economic evaluation studies aiming to analyse the application of methodological principles and to offer summaries of papers classified by either diseases or health technologies.  These reviews are useful to detect literature trends, targets of the studies and possible deficiencies in the implementation of the methods to specific health interventions.