OBJECTIVES: Multiple sclerosis (MS) is a neurodegenerative disease associated with significant impairments in health related quality of life. This analysis was to identify patient factors associated with utility in RMS patients and to derive disutility values according to relevant disease stages. METHODS: TEMSO (N=1088) was designed to assess efficacy and safety of teriflunomide, a novel oral disease modifier, in RMS patients. The utility score, a measure of health-related quality of life, was calculated via the EQ-5D questionnaire assessed alongside the trial. Using baseline data, a cross-sectional analysis was performed to identify factors associated with utility scores using a multivariate regression linear model. This model includes the following factors; expanded disability status scale (EDSS) score, type of multiple sclerosis (relapsing remitting (RRMS) versus progressive relapsing (PRMS), region, number or relapses within the past 2 years, previous MS medication, gender, time (years) since first diagnosis of MS and burden of disease defined by magnetic resonance imaging. RESULTS: Three variables demonstrated a significant negative impact on utility values: the functional disability level as assessed by EDSS score (when EDSS score increases), PRMS versus RRMS and Eastern European countries versus North American countries. The major influencing factor, consistent with other analyses, was the EDSS score with the following disutility estimates: EDSS[1-2[=-0.021, p=0.52; EDSS[2-3[=-0.081, p=0.0128; EDSS[3-4[=-0.176, p<0.0001; EDSS[4-5[=-0.237, p<0.0001; EDSS[5-6[=-0.231, p<0.0001; EDSS[6-7[=-0.257, p<0.0001]. In addition, disutilities associated with PRMS versus RRMS and Eastern Europe region versus North American were respectively -0.073 (p=0.0028) and -0.038 (p=0.0361). CONCLUSIONS: In RMS patients, these results confirm the major impact of functional disability on patients’ utility. These analyses also provided disutility estimates per EDSS score, disutilities for PRMS versus RRMS and for Eastern Europe versus North American region. The later probably reflecting cultural differences in health status perception.