OBJECTIVES: The first official data on COPD prevalence, morbidity and mortality in Ukraine were introduced in 2009 report of National Center of Medical Statistics (2010). Nevertheless, there were no information on a number of specialists’ consultations, a number of disability days and hospitalizations’ frequency in Ukrainian COPD patient cohort. METHODS: Real-life 12 previous month’s data from the personal medical cards (90%) and interview-lists (10%) of II-III severity stage COPD patients were analyzed retrospectively. The study was conducted in three regional clinical centers Bila-Tserkva (Kiev region), Ivano-Frankivsk, Lutsk (Volyn’ region). Costs of COPD were calculated through the analysis of a number of GPs’ and pulmonologists’ consultations, a number of lost working days due to COPD, and COPD related hospitalizations frequency during the last 12 months. Direct medical costs included outpatient costs (specialists’ consultations, control spirometry once a year) and inpatient costs (diagnostic measures and hospital-service costs), indirect costs included productivity loss (absenteeism and presenteeism) and disability compensations. The 2010-2011 medical service inflation (11.45%), salary growth rate (25%), social tax (18.6%) and Value Added Tax (17%) discounted the calculations. Exchange rate: 1EUR = 11.42UAH on 18.06.2011. RESULTS: The total study sample contained 132 patients, aged from 24 to 65 (mean age 49.49±10.02), males - 60.61 %. The number of GPs’ and Pulmonologists’ consultations per COPD patient was 2.63 and 1.18 per year respectively. The number of lost working days due to COPD was 12.63 per patient annually and a frequency of COPD related hospitalizations was 0.56 per 12 months. The total COPD costs in Ukraine in 2009 were €38870506 (103.03 per patient) with €28448213 (73.8%) direct medical costs and €10422293 (26.82%) indirect costs. CONCLUSIONS: The pilot study results showed that costs per COPD patient in Ukraine are large and could correspond with costs in several EU countries. Nevertheless, COPD in Ukraine is underdiagnosed and underestimated.