OBJECTIVES: Testicular cancer (TC) is the most common cancer in young men and its incidence is increasing. The low mortality rate makes quality of life (QOL) an important issue in this patient group. Thus, this study aimed at monitoring QOL, and patient-reported physical and psychosocial symptoms. METHODS: Patients with TC treated at the urological outpatient unit of Innsbruck Medical University were consecutively included in the study. QOL assessment was done with the generic EORTC QLQ-C30 questionnaire and recently also with the TC-specific EORTC QLQ-TC26 (scale range 0-100). For electronic data capture and result presentation to physicians we used a software tool called Computer-based Health Evaluation System (CHES). RESULTS: Since January 2008, we included 408 patients in the electronic patient-reported outcome monitoring with a total of 1087 symptom assessments. Mean patient age was 43.3 years (SD 11.9). To optimize patient recruitment and data quality a person was needed for approaching patients actively and to provide support in case of any questions arising. Collected symptom data enables longitudinal tracking of symptoms and screening for symptoms that patients do not volunteer within the patient-physician contact. Overall, most pronounced TC-specific symptoms were negative future perspective (mean 58.1), reduced sexual activity (mean 60.2), and impaired sexual enjoyment (mean 69.7). CONCLUSIONS: Patient-reported outcome monitoring was found to be feasible in the busy setting of an urologic outpatient unit. As TC patients are of younger age than most other cancer patient groups, electronic data collection is particularly feasible, given the high computer literacy in these patients. The software CHES used for electronic data capture was found to provide high user friendliness for patients as well as physicians. The data base created within this study allows comprehensive analyses for a range of research questions.