OBJECTIVES: Drug use review for the treatment of asthma and assess the impact of the administrative program to optimize the use of drugs in the Samara region in 2008-2010. METHODS: In 2008 retrospective analysis of drug use in ambulatory practice based on a database of 90,196 paid prescriptions patients with bronchial asthma in the Samara region. An analysis of 155 history of 15 clinics. Data on the consumption of drugs were presented with the ATC/DDD methodology in the form of DDD/1000 inhabitants day. After the analysis has developed a program that includes training, administrative controls over the discharge of drugs, medications, and form a formal application form. In 2009, the evaluation of the implementation of the optimization program by re-examining the consumption of drugs (105 318 prescriptions paid for) and analysis of hospital records (143 history) RESULTS: Use of basic products in 2008 amounted to 380, including inhaled corticosteroids (ICS) was 286, medications to relieve symptoms - 485 DDD 1000 inhabitants/day. In 2009, use of basic drugs increased by 1.6 times to 621, the consumption of inhaled corticosteroids has increased by 1.7 times to 502 DDD per 1000 inhabitants/day, (p <0.001). In 2009 compared to 2008 the number of patients with nocturnal symptoms dropped from 52% to 37%; of hospitalization from 47% to 25%; ambulance call from 40% to 23%, respectively (p <0.001). CONCLUSIONS: The introduction of a rational program for the use of drugs with the use of administrative controls in 2009 allowed the drug to optimize the consumption of patients with asthma to improve asthma control in clinical practice and to reduce the costs of the use of medical resources