OBJECTIVES: To assess an economical burden of HPV associated diseases in Saint-Petersburg. METHODS: Total lifetime costs (direct and indirect) of HPV-associated diseases (cervical cancer, cervical dysplasia – CIN I-III, and condylomatosis - genital warts) in one cohort (13 years old girls in 2010; life expectancy - 74 years; cohort amount - 16 thousands) were estimated. Epidemiologic forecast was prepared based on mathematical-statistical modeling with least-square method of regression analysis on parent observation matrix. Raw epidemiologic data on morbidity and mortality were derived from official statistics. Cost of treatment was calculated using current out-patient and hospital tariffs (in obligatory medical insurance program) and standards of treatment (as of 2009). Indirect costs (gross output underproduction, disability pension, sick-pay etc.) were assessed based on existing legislation (Federal and Saint-Petersburg's regional). No discounting was applied in the analysis. RESULTS: Rates (per 100 000 female population) of dysplasia, genital warts, and cervical cancer incidence, and death were 16.5, 38.7-59,7, and 13.1-17.3, and 7.1-9.6, respectively. 10 years' growth of cervical cancer incidence and mortality was expected to be 12-15% and 8-15% (in different age groups), respectively. Total annual economic burden due to HPV diseases was 822 mln. Rub which includes: 72 mln. Rub – treatment of cervical cancer, 637 mln. Rub – indirect costs due to cervical cancer; 89 mln. Rub – dysplasia, 20 mln. Rub – genital warts. Sum of total cost in one cohort was 1.1 billion Rub. CONCLUSIONS: Economic burden of HPV-associated diseases in Saint-Petersburg in one cohort expected to be 1.1 billon Rub.