OBJECTIVES: To assess the cost-effectiveness of universal rotavirus immunization, explicitly the use of Rotateq® and affordability of implementing rotavirus immunization based on the Global Alliance for Vaccines and Immunization (GAVI)-subsidized vaccine price in the context of Vietnamese health care system for the next 5 years.  METHODS: An age-structured cohort model was developed for the 2009 Vietnamese birth cohort and applied a 5-year time horizon with time cycle of 1 month for < 1-year-old children and annually thereafter. Results from no vaccination and vaccination were compared. Outcomes included rotavirus episodes requiring home-treatment, outpatient visits, hospitalizations and deaths. Multiple outcomes per rotavirus infection are possible in the model. Acceptability and affordability analyses were done using Monte Carlo simulations. Costs were expressed in 2009 US$. RESULTS: Rotavirus immunization would not completely protect under-five-year-old children against rotavirus infection due to partial nature of vaccine immunity, however, would effectively reduce rotavirus severe cases by ~55%. Under the GAVI-subsidized price, the minimum vaccination budget would be US$1.6 million annually. In the base-case, the incremental cost per quality-adjusted-life-year (QALY) was US$665 from health care perspective,

Conference/Value in Health Info

2011-11, ISPOR Europe 2011, Madrid, Spain

Value in Health, Vol. 14, No. 7 (November 2011)

Code

PIN72

Topic

Economic Evaluation

Topic Subcategory

Cost-comparison, Effectiveness, Utility, Benefit Analysis

Disease

Infectious Disease (non-vaccine), Vaccines

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