OBJECTIVES: In CT imaging, as preparation procedure for contrast media (Iopromide), the use of prefilled cartridge (PFC) is simpler compared to glass bottle (GB). There are several benefits such as infection control and time saving. This study examined the benefits of contrast media with PFC compared to GB. METHODS: The benefits are defined as the cost savings which can occur when used in various situations. A decision analytic model was created to evaluate the effectiveness according to the type. The use of each type could finally lead to local infection and blood stream infection (BSI). We estimated the benefits using the probability of infection from decision model and treatment costs from insurance claims data. To estimate the benefits of time saving, we measured the preparation time repeatedly in general hospitals. Assuming that the reduced time was replaced with CT scan in new patients, we estimated the time saving benefits by multiplying the result to the cost of CT scan. RESULTS: The material cost of GB was $74.8 which is higher than $72.9 of PFC. In contrast, in case of GB, the probability of contamination, local infection and BSI were 3.3%, 1.25%, 0.060% respectively, which were higher than PFC (0%, 1.22%, 0.058%). The benefit in reduction of infection was estimated at $0.20 per case in PFC. The reduced time from using PFC has an average of 51.9 seconds based on 113 observations from 3 general hospitals. The time saving benefit was estimated at $7.16 per case. Therefore, the total benefit was estimated at $7.36. CONCLUSIONS: This study showed that PFC dominated GB (lower costs, and higher benefits). This was driven by lower material cost, lower infection risk and administration time for PFC compared to GB. Findings of this study suggest that the use of PFC contrast media is an efficient utilization of resources in Korea.