OBJECTIVES: In advanced or complicated Parkinson’s disease (CPD), among other treatment alternatives, patients can receive deep brain stimulation (DBS) or continuous duodenal levodopa-carbidopa infusion (CDLCI). This pilot study was designed to understand the preferences of patients who face these treatment choices.  METHODS: Treatment attributes were identified based on a literature review, focus groups with patients, caregivers, and interviews with clinicians.  A discrete choice experiment survey was developed, reviewed by clinicians and piloted with patients.  Patients (potentially considering DBS or CDLCI) in Spain (n=30) and the UK (n=10) completed the survey .  Treatment attributes included surgery type, impact on daily life, medication need, speech difficulties, movement control, dyskinesia, and off-periods. Data were analyzed using a multi-level hierarchical logistic model.  RESULTS: Surgery type (DBS electric lead insertion in the brain vs CDLCI intraduodenal tube placement) was the most powerful predictor in the model, with a preference for DBS over CDLCI  (OR= 8.02, 95% CI=6.17-10.38).  Avoiding deterioration in movement was also important in determining treatment choice (OR=0.67; 95%CI=0.57-0.79) as was avoiding limitations on daily activities; (OR=0.69; 95%CI=0.54-0.88).  CONCLUSIONS: CPD patients were able to engage in this quite complex task to indicate their views regarding treatments.  Participants had a preference for DBS surgery type. Maintaining movement and daily activities were also important attributes.  As the surgery attribute was a composite of both surgical procedure and daily maintenance, further study is needed to identify which of these aspects is the strongest predictor of patient preferences. Finally, a larger study is needed to understand the importance of attributes for all the treatment alternatives that can be offered to CPD patients