Objective: Patients are increasingly getting involved in making their treatment decisions, however, options for obtaining satisfaction information from other patients on their medications is limited primarily to on-line blogs. Using a validated PRO instrument to capture and disseminate feedback in a structured, unbiased way could be a valuable service to patients. The Treatment Satisfaction Questionnaire for Medication Version I (TSQM) is a 14-item reliable and valid instrument to assess patients' satisfaction with medication, providing scores on four scales—side effects, effectiveness, convenience and global satisfaction. This study discusses preliminary results on satisfaction with ten different chronic medications from a novel patient registry. Methods: The registry recruited patients from multiple sources including physicians, pharmacies, and online referrals. Patients were asked to report ongoing medications on the project website (www.iGuard.org). A sample of patients were contacted to complete the TSQM. The current analysis captures data from patients on any of the following ten chronic medications—acetylsalicylic acid, atorvastatin, simvastatin, lisinopril, metoprolol, metformin, levothyroxine, salbutamol, fluticasone/salmeterol or sertraline (n=495). Analyses were conducted to explore differences in patients' satisfaction across medications. Results: The mean age (SD) of the patients was 54.1 (14.2) years: 62.7% were females, 91.6% Caucasian and 3.7% black. The TSQM domains had good internal consistency with Cronbach's alpha for all domains exceeding 0.85. The number of respondents was more than 30 for all but one medication. The mean TSQM scores ranged from 67.3 (metoprolol) to 76.1 (atorvastatin) on effectiveness, from 77.3 (metoprolol) to 95.3 (acetylsalicylic acid) on side effects, from 77.3 (salbutamol) to 87.7 (simvastatin) on convenience and from 60.9 (metoprolol) to 78.0 (levothyroxine) on global satisfaction. Differences were observed in TSQM domain scores between medications used for treating the same medical condition. Conclusion: Comparative data on patients' satisfaction with medications can provide useful information to patients when starting a new medication or comparing their own experience.