Objective: Three focus groups were conducted as a preliminary step in a broader initiative to develop a single comprehensive ASTHMA-CAT assessment that combines asthma impact, asthma control, and generic health-related quality of life (HRQOL) measures in one “seamless” administration, and displays results in tandem in a real-time patient feedback report. Methods: The sample included 22 English-speaking, non-smoking adults (24-59 years) from the Boston area self-reporting asthma (36% controlled, 27% somewhat controlled, 36% uncontrolled). Participants (64% women; 77% Caucasian, 18% African American, 5% Asian; 14% Hispanic) identified areas of HRQOL impacted by asthma, and suggested content and format revisions to a survey and feedback report. Focus groups were taped and transcribed, and thematic content analyses were conducted. Results: Participants identified physical (e.g., difficulty staying physically active, increased susceptibility to secondary infection), social (e.g., avoiding places where there may be environmental triggers), and emotional (e.g., anxiety or worry; feeling a loss of control) aspects of health most impacted by asthma. While participants generally reported that items were clear and easy to understand, they noted content redundancy, identified potential improvements to examples contained within item stems, and indicated difficulty attributing health impact solely to asthma. Participants were interested in feedback reports that showed their progress over time, with sufficient score interpretation, and saw value in sharing results with their doctor. Conclusion: Focus group participants identified core areas of HRQOL affected by asthma and provided useful recommendations for improvements to survey content and reporting features of the ASTHMA-CAT assessment. New and revised item content will be evaluated in future quantitative studies, and final design features will be evaluated in usability testing.