Objective: To describe gastroesophageal reflux disease (GERD) patients who are partial responders to treatment of proton pump inhibitors (PPI) in terms of their health care utilization, quality of life and work productivity. Methods: The analysis is based on the National Health and Wellness Survey (NHWS) conducted by the Consumer Health Sciences (CHS) in USA 2006. Partial responders are defined as diagnosed GERD patients with remaining at least moderate symptoms 4 times/week or more after two months PPI-treatment (n=1433). This group is compared to 1) GERD patients with only mild symptoms or moderate to severe symptoms less than 4 times/week after a short course of PPI treatment (n=281), and 2) all individuals, excluding partial responders, who self-reported GERD, (n=19,817). Results: Partial responders use PPI on average 24.5 days/month which is 7.4 days more than patients responding well and 1.2 days more than all GERD patients. The SF-8 physical summary score is 38.6 for partial responders, which is 5.3 points less than for patients responding well and 7.4 points less than for all GERD patients. The mental summary score for partial responders is 41.9 which is 4.3 and 4.6 points less for patients responding well and all GERD patients, respectively. Partial responders lost 10.9 hours per week due to reduced productivity at work, which is 2.4 hours more than for patients responding well and 3.8 hours more than for all GERD patients. Partial responders consume resources and impose total productivity losses equivalent to $2603 per month, which is $724 more than for patients responding well and $1162 more than for all GERD patients. Conclusion: Partial responders to PPI treatment are more costly and score lower on physical and mental dimensions of HRQoL than patients responding well to PPI treatment and GERD patients in general.