Objective: Compare the effectiveness and costs of the administration of an ophthalmic Meloxicam solution 0.030% with a sodium Diclofenac solution 0.1% on the eyes of patients who underwent to Lasik laser eye surgery at the immediately postoperative time. Methods: Adopting the perspective of a health care payer, we developed a cost-effectiveness analysis. Temporary horizon was three months. A discounting rate was not used. The source of information of cost and effectiveness was a randomized clinical trial. The perspective was from Mexican Institute of social Security. The method used for cost was microcosting and case mix. The effectiveness was measured with different end points. The cost-effectiveness analysis was made for those variables with statistically significant differences. The evaluation was made with incremental analysis and net benefits approach. The sensitivity analyses was of one way, two ways and probabilistic. Results: The highest cost was with Diclofenac solution (USD$9.29) that was 5.9% higher than Meloxicam ($8.74) the measured efficacy named Flare and ciliary injection was superior with Meloxicam compared with Diclofenac 148 vs. 149 for Flare and 150 vs 153 respectively (p<0.0001) for ciliary injection, the cost for success obtained with Meloxicam was of USD$8.74 and USD$9.29 with Diclofenac, the incremental analysis show that Meloxicam is dominant over Diclofenac. Health Net Benefits, Monetary Net Benefits and the Acceptability curves were favourable for Meloxicam independent the willingness to pay. Conclusion: The Meloxicam solution was dominant over Diclofenac in the application on the ocular surface in patients who underwent to Lasik laser eye surgery in the immediate postoperative period. The sensitivity analysis was a robust basis for the study.