Objective: There is limited experience with patient-reported health status and health-related quality of life (HRQL) in survivors of cancer in childhood in low-income countries. The purpose of this study was to collect these measurements in Brazil, test hypotheses about differences among diagnostic groups, and compare the results with those from other countries in an overall assessment of the construct validity of the HUI3. Methods: Survivors were eligible if: diagnosed with cancer in childhood; attending the long-term follow-up clinic for one treatment center; at least 8 years off therapy; cancer free, literate; and at least 13 years of age. Health status measurements were collected in the clinic using a Brazilian Portuguese Health Utilities Index self-report questionnaire. Responses were converted to attribute levels, and utility scores for morbidity in individual health attributes and for overall HRQL, using standard HUI Decision Tables and Utility Functions. Standard t-tests and 1-way ANOVA were used to analyze HUI3 utility scores within and across diagnoses and between countries. HUI3 overall HRQL scores were categorized to mild / moderate / severe disability (1.00=No disability, 0.89-0.99=Mild, 0.70-0.88=Moderate, <0.70=Severe disability). Results: A total of 138 consecutive survivors participated in the survey. More than 71% reported some disability (mild-moderate-severe). More than one-third reported some cognitive disability and/or pain while approximately one-quarter reported problems with vision, speech or emotion. As hypothesized, retinoblastoma survivors had significant visual morbidity (p=0.048). Survivors of germ cell tumors had significant pain morbidity (p=0.003) and lowest mean HRQL utility score (0.49) among the diagnostic groups. HRQL means of survivors were similar (p>0.05) among countries (Brazil, Canada, Central America, Uruguay) within diagnostic groups of acute lymphoblastic leukemia and hodgkin's disease. Conclusion: The results show that the Brazilian survivors experience a wide range of disabilities and impaired HRQL similar to those reported in other countries and affirm the construct validity of the HUI3.