Objective: Due to the increasing costs for antibiotics and increasing resistance in Slovakia the educative project S-MedDial was established in the cooperation with professional companies, under the guarantee of the General Health Insurance Fund. The project evaluates prescription habits in respiratory infections, monitors antibiotics resistance for main bacterial pathogens and provides individual feedback to paediatrists with the aim to rationalize the antibiotics prescription and to decrease the resistance risk. Methods: Antibiotic prescription habits were analysed from 2003 to 2006 for 73 doctors in 5 region based on both the prospective data from protocols (14537 protocols in y.2006) and the retrospective claims insurance data. Analysis was based on the established comparison system of prescription profiles and individual feedback was provided to each practitioner during regional meetings of project members. Results: Every second child with respiratory infection was treated with antibiotics. In the whole patient group the most frequently indicated drugs were macrolides (25.9%), followed by basic penicillins (20.4%) and penicillins potentiated with beta-lactamase inhibitors (19.9%). Macrolides were most frequently prescribed in region Bratislava (37.3%) and Nitra (35.4%). In region Presov there were aminopenicillins potentiated with beta-lactamase inhibitors indicated mostly (22.5%), in Trebisov broad-spectrum penicillins (28.4%) and in Zvolen basic penicillins (30%). From macrolides the most frequently prescribed was azitromycin followed by claritromycin. In all cooperating regions the antibiotics costs were reduced by 5.1% per patient. Significant differences in antibiotics prescription in regions were not only in the number of indicated antibiotics but also in their spectrum. The usage of antibiotics in the prospective study was decrease the most in Presov, from 67.8 % to 49.6%. Conclusion: S-MedDial project represents an option for increase of antibiotics prescription quality while using the prescribing practitioners' education. Analysis of antibiotics prescription habits is suitable not only for cost control but also for antibiotics prescription implications on resistance trends.