OBJECTIVES: The Glasgow Health Status Inventory, (GHSI) measures the effect of a health problem on the quality of life of a person and allows cross-comparison among many health conditions, among different health interventions, and among demographic and cultural subgroups.  The GHSI contains 18 health status questions, which ask specific questions about how the health problem has affected their quality of life. This study aims to adapt the GHSI into Turkish culture and check the reliability and validity of the inventory culturally. METHODS: The original instrument was translated and back translated by two independent translators. A small sample consisting of 40 people was used to check the initial comprehension and factibility. Cronbach’s Alfa was used to assess reliability and factor analysis to assess dimensionality. The EuroQol questionnaire and corresponding Visual Analogue Scales were used for concurrent validity. RESULTS: A total of 163 people participated in this study. 52% of them were female, 48% of them were male. Mean age was 24.3. The internal consistency coefficient (Cronbach's alpha) of GHSI was 0.86. Factor analysis of the scale revealed that it was composed of four factors with Eigenvalues >1.0, accounting for 62.2 % of the total variance. Correlations were moderate with EuroQol and VAS. CONCLUSIONS: The culturally adapted GHSI has good validity and reliability, making it a potentially useful outcome measure in the determining the effect of health problems on the quality of life of people in Turkey.