OBJECTIVES: The purpose of this study was to describe health-related quality of life (HRQL) of overweight  and obese patients seeking care at the Pharmaceutical Care Service of the Proveeduría Farmacéutica IPP-UCV.   METHODS: A convenience sample of 49 patients, ranging in age from 18 to 83 years was surveyed using a written questionnaire from February 2010 to May 2010. HRQL was measured using EuroQol comprising the health states descriptive system (EQ-5D) and visual analogue scale (EQ-VAS) as a general instrument. RESULTS: The sample consisted of 42 females and 7 males. The sample had a mean age of 48.55 years (s.d. 15.25 years). The mean weight of patients was 82.88 kg (s.d. 18.24). The mean body mass index (BMI) of the patients was 31.99 kg/m2 (s.d 5.77). Thirty-eight patients (77.6%) reported no exercising regularly. Thirty-four patients (69.4%) reported some problems with mobility. Seven patients (14.3%) reported some problems with self-care. Thirty-eight patients (77.6%) reported some problems with usual activity. Twenty-five (51%) patients reported some problems and 18 (36.7%) reported extreme problems with pain. Nineteen subjects (38.8%) reported extreme problems and 17 reported some problems with anxiety. CONCLUSIONS: Study limitations include the sample size and the use of a convenient patient sample. Overall, this exploratory study demonstrates that nearly all aspects of HRQL are adversely affected in overweight and obese patients seeking care at a pharmaceutical care service in Venezuela.