OBJECTIVES: In March 2010, President Barak Obama signed the Patient Protection and Affordable Care Act (PPACA), which radically changed the healthcare landscape in the United States. We carried out a survey to gauge consumers’ opinion about the U.S. health care system after the PPACA was signed into the U.S. law. METHODS: We commissioned Harris Interactive to conduct a nationally representative telephone survey of 1,019 adults from the U.S. between May 21-24. Respondents were questioned on their current insurance coverage status, their knowledge about the PPACA, and their perception of the reform. Data were weighted to be representative of the total U.S. adult population in terms of age, sex, geographic region and race. The survey has a sampling error of ±3% at 95% confidence level. RESULTS: 84% of all adults surveyed have an health insurance; 96% of adults 65 years old and above have health insurance. Overall, while 36% of all adults surveyed think they will be “better off” as a result of the reform; 43% think they will become “worse off”. 61% of respondents said they are “very knowledgeable” or “somewhat knowledgeable” about the PPACA; 54% of adults surveyed who rated themselves as “very knowledgeable” think they will be “worse off” as a result of the bill.  Adults surveyed anticipate an increase in tax (76%), hospital and physician prices (65%), health insurance cost (65%) and cost of medications (54%). CONCLUSIONS: According to the survey, while the majority of consumers are satisfied with their current health care coverage, many have concerns about potential changes from PPACA. Concerns include health insurance coverage, access to quality health care and potential cost increase. In addition, the majority of consumers said that they are at least somewhat knowledgeable about PPACA.