OBJECTIVES: The objective of this study was to determine factors affecting the population’s decision to get vaccinated against the influenza H1N1 virus. METHODS: Data for this study was obtained from a Panhellenic survey, organized by the National School of Public Health of Greece. The sample (n=12,639) was drawn from strata of various degrees of urbanization and geographical region. The primary outcome of the survey was the intent to get vaccinated for H1N1; logistic regression was used to identify significant potential determinants. RESULTS: The decision of vaccination for influenza virus H1N1 was associated with factors related to education, income, interaction between education and income, gender, trust to Public Health Organizations and perceptions about the health effects of influenza virus H1N1. Individuals of higher education and income, do not intend to get vaccinated. This also holds for individuals who express low degree of trust to or believe that the H1N1 virus is not a serious threat to human health. CONCLUSIONS: We identified several socioeconomic and demographic factors affecting individual intent to get vaccinated for H1N1.  Personal beliefs about the health effects of H1N1 virus and trust to Public Health Organizations were also significant predictors of vaccination intent.