OBJECTIVES: To estimate the burden of post-menopausal osteoporosis-related fracture hospitalizations in France for acute and rehabilitation care. METHODS: Data were obtained from the 2008 French Hospital National Database for women aged ≥50 years. For acute care, criteria were established according to ICD-10 codes related to osteoporosis. As the rules of coding are not strictly followed in real practice, an additional database analysis was performed to include stays related to surgical management of hip fractures. Duplicate hospitalizations were excluded. Among women that were identified for acute care, we selected those who went in rehabilitation care related specifically to osteoporosis. We assessed number of hospitalizations and patients, proportion of surgical management, length of stay in acute care and number of rehabilitation day and costs. Hospital costs were calculated according 2009 national hospital tariff and 2000-2001 National Scale of Costs, respectively for acute and rehabilitation care (2009€). RESULTS: There were 67,807 acute hospitalizations (64,793 patients) and 1,359,863 days for rehabilitation care (31,458 patients) associated with osteoporosis-related fractures. In acute care, a total of 80% of the hospitalizations were associated with the surgical management of fractures and 89% of them were transferred in rehabilitation care. The mean (SD) length of stay and days of rehabilitation were 12 ± 8 days and 43 ± 31 days, respectively. The overall cost of osteoporosis-related fracture hospitalizations was 415,429,993€ for acute care, of which 6.5% was related to medical devices, and 331,755,797€ for rehabilitation care. The mean (SD) hospital cost including medical devices, was 6,127€ ± 2,352€ per stay for acute care and 10,546€ ± 7,869€ per stay for rehabilitation care. CONCLUSIONS: In 2008, osteoporosis-related fracture hospitalizations were associated with a substantial economic burden in France.