OBJECTIVES: As in most countries, Diabetes Mellitus is a disease causing significant burden to Turkey. The treatments and their benefits affect not only the patient, but their friends, families and other relationships as well. Therefore, feedback regarding the quality of life of a Diabetes Mellitus patient is meaningful. The aim of this study was to determine the reliability and validity of the Diabetes Health Profile-1 (DHP-1) for Turkish Diabetic patients.  METHODS: The scale, which was translated into Turkish from English, again translated back into English by 2 independent translators, was applied to 45 diabetic patients for pre-test.  After assessment of the results, the questionnaire was applied to 60 diabetic patients. Cronbach’s Alfa was used to assess reliability and factor analysis to assess dimensionality. The EuroQol-5D was used for concurrent validity. RESULTS: The internal consistency coefficient (Cronbach's alpha) of DHP-1was 0.86. Factor analysis of the scale revealed that it was composed of five factors with Eigenvalues >1, accounting for 74.4%  of the total variance. All items of the Turkish DHP had a factor load ranging from 0.578 to 0.838. CONCLUSIONS: The DHP-1 has good validity and reliability for Turkish Diabetic patients.