OBJECTIVES: The aim of this study was to evaluate the impact of symptoms related to Parkinson’s disease (PD) on health-related quality of life. METHODS:    Observational, multicenter, cross sectional study in patients with PD, older than 18, who had received PD medication for at least 1 year before inclusion. The following assessments were applied: Hoehn and Yahr staging of PD (HY), SCOPA-Motor (SC-M), Non-Motor Symptoms Questionnaire (NMSQ), QUICK Questionnaire (QQ, for detection of wearing-off, WO) and PDQ-39 to evaluate quality of life in PD patients. RESULTS: 1.173 evaluable patients were included, 58.6% were males, mean age (SD) was 71.4 (8.6) years and most of them were in HY stage 2 or 3 (70.3%). According to SC-M, 94.5% patients presented rigidity, 93.1% rapid alternating hand movements and 84.5% alteration of walking. Mean score of SC-M and NMSQ was 19.3 (12.6) and 9.7 (6.1) points, respectively. Regarding the quality of life evaluated using the PDQ-39 questionnaire, global score was 26.6 (18.6) points. Spearman correlation coefficients between PDQ-39 and the other measures were: HY, 0.55; SC-M, 0.76; NMSQ, 0.73; and QQ, 0.67. 59.2% patients presented WO according to QQ. Quality of life was better for patients without WO: PDQ-39 score 20.0 (17.4) vs 30.8 (18.2) points in patients with WO (p<0.0001). CONCLUSIONS: The results of this study suggest that Parkinson’s disease patients present a combination of motor and no-motor symptoms which affects quality of life. The presence of wearing off affects also the quality of life of these patients.