OBJECTIVES: To develop a brief self-administered questionnaire able to measure patient satisfaction with treatments of skin diseases of the hands, with good psychometric properties. METHODS: An initial version of the questionnaire composed by 38 items, organized in 6 dimensions, was proposed. Items were extracted from 3 patient’s focus-groups and ratified by a 7 expert panel and were presented to a pilot sample to test comprehension. This full version was administered to a sample of 217 patients with skin diseases of the hands recruited at 18 representative hospitals in Spain. In order to assess convergent validity Morisky-Green compliance scale, SF-12 HRQoL questionnaire and a health status VAS were also used. Treatment effectiveness and tolerability were also measured. Exploratory factor analysis was used for item reduction and confirmatory factor analysis for dimensionality assessment. Internal consistency and split-half methods were used for reliability. Item discrimination and kwon group’s validity (gender, age, severity, and treatment) were also assessed. RESULTS: The reduction and validation sample was composed by 54% women, and a mean age of 43 years (sd=13.7). Questionnaire was reduced to 17 items arranged in 6 dimensions: Efficacy, Ease of use, Impact on HRQoL, Follow up, Undesired Effects, General Opinions. Cronbach’s alpha attained a 0.9 value. Dimensions exhibited levels of correlation different from those found previously from questionnaires for other pathologies. The overall score distributed normally with 58.4 mean (sd=18.01). Dimension scores correlated within 0.003 and 0.222 with HQoL measures, correlated higher with effectiveness (r=0.41) and tolerability (0.22), but very low with compliance (0.015). Significant differences were found between some diagnoses and treatments. CONCLUSIONS: The reduced questionnaire presents good psychometric properties, with an excellent reliability and good initial validity evidences.