OBJECTIVES: Migraine is a common and disabling condition.  Real-world health care resource utilization and patient reported outcomes data are important for documenting the burden of illness and are necessary inputs for economic models.  An efficient and adaptable methodology for the conduct of international health economic and PRO data gathering is described. METHODS: An IRB approved, web-based, cross-sectional survey of headache sufferers was conducted in 9 countries (US, Canada, Australia, UK, Germany, France, Spain, Italy, Taiwan).  Registered panelists received email invitations in their country’s language and provided consent from a web link option; non-migraineurs were excluded on the basis of reported symptoms, and eligible subjects were classified as either chronic (≥15 headache days per month), episodic (1-14), or potential migraineurs (migraine-like symptoms).  Survey enrollment was rolled out in waves and completed when targeted sample of chronic migraineurs was obtained. Survey outcomes included sociodemographic, headache symptoms, resource utilization, disability and productivity from HIT-6, MIDAS, MSQ v2.1.  Validation rules were pre-programmed to enhance data quality. RESULTS: Of 63,001 survey invitees, 20,987 responded. A total of 9118 completers (14.5%) comprised the final cohort (n= 516 ( Australia) - 1597 (US)); 83.6% female; mean age 41 (± 12) years; 499 (5.5 %) chronic migraineurs. Mean study period across countries was 12.6 days; results were available within 3-5 days after study completion. The core survey required minimal adaptation for international use beyond translation, permitting both country-specific and pooled analyses.  Main challenges included adapting questionnaires to a web-based format and predicting eligibility rates for countries without pre-screened headache survey candidates.  Despite inherent limitations of on-line studies, particularly generalizability, the observed proportion of chronic to episodic migraineurs within a headache population was consistent with other published reports using mailed questionnaires.  CONCLUSIONS: International, web-based, patient-reported surveys are a method of collecting clinical, resource utilization and PRO data, while minimizing time and cost.