OBJECTIVES: The assessment of quality of life among ambulatory patients with hypertension (HTN), diabetes type 2 (DM2) or coexisting HTN and DM2 (HTN+DM2). METHODS: Patients of 4 ambulatory care setting in Cracow (Poland) with HTN, DM2 or HTN+DM2 were included. Polish versions of SF-36v.2 and EQ-5D were used with the supplementary questions about age, gender, education, body mass, place of residence. Student’s t-test was used to compare  the differences between paired groups. RESULTS: A total of 135 patients were included (68 with HTN, 22 with DM2, 45 with HTN+DM2); 57,8% of patients were women. 31,11% of patients with HTN+DM2, 36,77% of patients with HTN and 72,73% of patients with DM2 assessed their health status as well, none indicated the answer excellent or very good. Usually women indicated their QOL lower than men (HTN: PF, RP, PCS p<0,05; HTN+DM2: PF, PB p<0,05). PCS was rated lower or similar to MCS; HTN: PCS 39,30±7,88, MCS 40,45±10,96, DM2: PCS 42,77±8,22, MCS 42,23±9,86; HTN+DM2: PCS 38,89±9,05, MCS 42,66±10,66.  Due to EQ-5D 80% of patients had no problems with self care and 60% - with usual activities. Over 85% of patients had moderate or extreme pain or discomfort, more than 70% of patients felt moderately or extremely anxious or depressed. About 75% of patients with HTN and HTN+DM2 confirmed problems with walking around. On VAS scale, patients with HTN, DM2 and HTN+DM2 assessed their health state accordingly: 54,87±15,70, 59,14±21,06, 55,56±14,50, with no statistically significant differences between diseases and sexes. CONCLUSIONS: Patients with HTN and HTN+DM2 estimated their quality of life lower than patients with DM2.