OBJECTIVES: To determine the effect of an employer-sponsored pharmacist-provided medication therapy management program (MTMP) on clinical outcomes and social measures in patients with hypertension. METHODS: A prospective, intent-to-treat, pre-post longitudinal study. Patients were Lucas County employees and/ dependents with a diagnosis for hypertension. The face-to-face MTMP was provided by pharmacists from the Toledo Area Coalition of Independent Pharmacies at seven pharmacies. JNC-VII guidelines were used to design interventions and set patient goals. Interventions were provided every six months. Information recorded included demographic information, clinical markers and social measures. Data was documented by pharmacists or pharmacy technicians using intake forms. Data was analyzed using SPSSv 16.0 for two groups i.e. hypertension only (may have other comorbid conditions excluding diabetes) and hypertensive diabetics. Wilcoxon signed-rank test was used to compare 2 time points and the Friedman test was to compare readings at baseline, six and 12 months.   RESULTS: Two hundred and twenty eight patients have enrolled in the program. For the hypertension only group, mean systolic blood pressure (SBP) improved from 133.73 ± 17.36 to 130.86 ± 16.49 (p=0.112). For uncontrolled hypertensive patients in this group, mean SBP improved from 152.54 ± 11.80 to 139.77 ± 18.22 (p=.000). Diastolic blood pressure improved from 99.330 to 91.50 (p=0.049). For hypertensive diabetic patients mean SBP decreased from 135.64 ± 18.21 to 127.55 ± 15.26 (p=0.003). Significant decrease was also observed for hypertensive diabetic with uncontrolled blood pressure at baseline (146.26 ± 13.55 to 131.44 ± 13.66 mmHg; p=0.000). Mean alcohol and caffeine consumption decreased non-significantly for patients in both groups. CONCLUSIONS: Pharmacists interventions assisted uncontrolled patients in reaching their goal BP reading, and for controlled patients, helped in maintaining their level of control. Periodic monitoring by a pharmacist can assist patients in reaching their targeted goal and maintaining that value so as to prevent long-term complications and costs.