OBJECTIVES: Evaluation of the drug use is a system of continuous, systematic, criteria-based drug evaluation that ensures the appropriate use of drugs. Drug utilization research in itself does not necessarily provide answers, but it contributes to rational drug use. Antipsychotics are used to treat the symptoms of schizophrenia and bipolar disorders. A review of the cost and consumption for all medicines and antipsychotics in Croatia, as well as the data on medicine usage for these two groups are obtained. Collecting and analyzing the data on antipsychotic consumption may lead to the improvement of the antipsychotic therapy. METHODS: Agency for Medicinal Products and Medical Devices in Croatia collected and processed data on consumption of the medicines. Data on medicines usage between 2005-2007 was gathered, processed by the DDD/1000inh/day and ATC classification, and analyzed according to the financial indicators. RESULTS: The total medicines market in Croatia in 2005 was €520 million, in 2006 market was €562 million and in 2007 it was €564 million. By processing consumption data as DDD, between 2005-2007 consumption of N05A group the result was 8.30, 9.56 and 9.65 DDD/1000inh/day, respectively. Expenditure of antipsychotic drugs individually was as follows: haloperidol held the first place with 1.90 DDD/1000inh/day in 2005, 1.93 in 2006 and 1.94 in 2007. Promazine was second with 1.80 DDD/1000inh/day in 2005, 1.86 in 2006 and third with 1.89 in 2007. Olanzapine was third with 1.07 DDD/1000inh/day in 2005, 1.46 in 2006 and second with 1.92 in 2007. CONCLUSIONS: Within the period of 2005-2007, the processed antipsychotics in Croatia showed a continuous increase in prescribed DDD/1000inh/day. Haloperidol, promazine and olanzapine were the most prescribed drugs. By collecting and analyzing data useful for the improvement of pharmacotherapy, we also obtain information for the many other factors essential for the rational health care.