OBJECTIVES: One of the existing methods to assess the transferability of economic evaluations is the model of Welte, which is a decision chart method that includes general and specific knock-out criteria and a transferability checklist. This study aims to validate Welte’s model with the help of a case study. METHODS: In this study, foreign studies were transferred to the Netherlands and then compared with a Dutch reference study. Using the case study on non-specific subacute and chronic low back pain, the cost-effectiveness of physiotherapy was compared with a multidisciplinary treatment. With the help of a systematic search several foreign studies could be identified. Based on these foreign studies two different predictions regarding costs, effects and cost-effectiveness were produced for the Netherlands. In the “all studies predictions” all foreign studies were used. In the “Welte’s model predictions” only the foreign studies were used which passed the general and specific knock-out criteria. Both predictions were compared with the Dutch reference case. RESULTS: A total of fourteen non-Dutch studies were identified. Seven studies did not pass the general knock-out criteria and one study did not pass the specific knock-out criteria. The decision if a study was transferable was based on double retriever scores. As a result fourteen studies were included in the “all studies prediction” and six studies in the “Welte’s model prediction”. The predictions yielded different results and the “Welte’s model prediction” proved better on costs than the “all studies prediction”. The effectiveness predictions were least accurate for the “Welte’s model prediction”. Because of the small effectiveness difference no ICER predictions were calculated. DISCUSSION: Application of the model of Welte does influence cost and effects estimates when transferring economic data between countries. However, more cases should be subjected to the Welte transferability model before a final conclusion can be drawn.