OBJECTIVES: The aim of this study was to compare the one year Nd:Yag laser incidence rate of two multifocal intra-ocular lenses, ReSTOR® and Acrilisa®, implanted by a single surgeon following his usual practices METHODS: This retrospective study was based on all patients implanted with a ReSTOR® or Acrilisa® multi-focal lens since the third trimester of 2004 at one site. All patients with either cataract or clear lens were operated by the same surgeon. Characteristics of the subjects, as well as pre and post-op medical data were obtained from patient charts. One year post surgical data were obtained from the surgeon’s medical files and from other ophthalmologists, if any, involved in post-surgical care. Time to Nd:Yag laser analysis was carried out using Kaplan-Meier survival curves. Imbalance on confounding variables was adjusted with a Cox model. RESULTS: Eighty patients were bilaterally implanted with ReSTOR® and 76 with Acrilisa®. Patients with ReSTOR® were more often male (52.5% versus 30.7%; P<0.001) and younger (63.1 versus 65.8; P<0.001). After one year of follow-up, 3.7% of the ReSTOR® eyes had Nd:Yag laser versus 11.6% of the Acrilisa® eyes. Gender was not found to be associated with Nd:Yag laser while older patients were less prone to have capsulotomy (RR=0.91, IC95% [0.83-1.00], P=0.05). Eyes with Acrilisa® had 3.54 (IC95% [1.14-10.94]; P=0.03) more chances to have Nd:Yag laser than ReSTOR® eyes, after adjusting for age at surgery. CONCLUSIONS:This analysis conducted at one year suggested that following usual surgical practice in a private setting, ReSTOR® eyes had significantly less capsulotomy than those implanted with Acrilisa®.  Avoiding Nd:Yag laser and its potential complications is important, especially in a young population.  Analyses at two and three years will be required to confirm these findings