OBJECTIVES:

To assess the incidence and burden of bronchiectasis in patients with Primary Immunodeficiency (PI) diseases.

METHODS: The 2016 National Inpatient Sample (NIS) data set from the Healthcare Cost and Utilization Project was utilized in order to analyze hospital admission records for patients with PI. Two cohorts of patients were designed: PI with and without (w/o) bronchiectasis. Thirty comorbidities were assessed using Elixhauser scoring. Multivariate logistic regression was conducted to assess predictor variables for LOS and costs.

RESULTS:

In 2016, there were an estimated 114,100 hospitalizations with a diagnosis of PI, with approximately 3690 (3%) with a diagnosis of bronchiectasis. The mean age was 55.59 (SD 22.69) years, 45% were male and 78% were white. The mean hospital length of stay was 8.14 days and mean hospital charges were $87,836.

The top common comorbidities in PI+ Bronchiectasis patients were Hypertension 34%, Depression 20%, Cardiac Arrhythmias 19%, Weight Loss 18%, Congestive Heart Failure 17%, Hypothyroidism 17%, Renal Failure 15%, Rheumatoid Arthritis/Collagen Vascular 13%, Coagulopathy 12%, Pulmonary Circulation Disorders 11% and Diabetes 11%. The top diagnosis codes (other than PI and bronchiectasis) were hypogammaglobulinemia and Gastro-esophageal reflux disease.

CONCLUSIONS: Analysis of hospital records shows PI patients with Bronchiectasis incur significant resources and have a high rate of comorbid conditions. There is a need for new treatments to improve outcomes in these patients.