OBJECTIVES: To conduct economic evaluation study on dengue vaccines combined with the Wolbachia program by simplifying the previous Markov model.

METHODS: The research conducted a probabilistic analysis using data from the literature. We applied the payer perspective, time horizon of 10 years, and costs are presented in US dollars. Sensitivity analysis is performed to evaluate the effects of two interventions and epidemiological. The simulation is conducted using RStudio with BCEA package.

RESULTS: The analysis results presented that there is a possibility of moving from one stage to another. The incremental cost-effectiveness ratios (ICERs) are $1,564.83 per quality-adjusted life year (QALY) gained, incremental net benefit (INB) 2,026.4, and probability cost-effective value 0.8245, respectively.

CONCLUSIONS: It can be concluded that combination of vaccination and Wolbachia mosquitoes control is a cost-effective strategy to prevent dengue infection.