Objectives: The outbreak of COVID-19 may increase the risk of depression among Middle Eastern and North African (MENA) community given the additional stressors they face including immigration, encountering a new culture, and language barrier. We aimed to assess depression and its predictors during COVID-19 among MENA community in Houston, Texas. Methods: A cross-sectional study was conducted using a validated survey consisted of sociodemographic, general health, and COVID-19 questions. A multivariable logistic regression model was used to determine predictors of depression. The outcome of interest was “moderate/severe” versus “no/mild” depression and measured using the validated Patient Health Questionnaire (PHQ-9). Results: A total of 368 individuals completed the survey. The overall prevalence of “moderate/severe” and “mild” depression was 31.79% and 68.21%, respectively. Multivariable regression analysis revealed that people with self-reported depression (OR=2.76, 95%CI=1.15-6.65) and those expressed "I don't know" for having depression (OR=9.03, 95%CI=1.55-52.62) were more likely to have “moderate/severe” depression compared to participants reported no depression. Individuals who said “Yes” to the question "Has the COVID-19 outbreak been so frightening/upsetting that you tried hard not to think about it, or tried to avoid situations that reminded of it?" were more likely to have “moderate/severe” depression compared to those who said “No”. (OR=3.63, 95%CI=1.64-8.03). In addition, those having "no difficulty” (OR=0.13, 95%CI=0.03-0.51) and those having “some difficulty” (OR=0.20, 95%CI=0.07-0.56) doing errands alone because of a physical, mental, or emotional condition were less likely to have “moderate/severe” depression compared to those with "a lot of difficulty/can't do at all". Conclusions: Depression in the MENA community may be predicted by social and physical wellbeing, self-reported symptoms of depression and COVID-19 related factors. Predictors identified should be considered when designing interventions to improve the social and health needs of MENA group in the context of the existing racial and immigrant health in the US.