Health care and the broader economy interact of course, but in normal times we ignore these interrelationships, hoping it is safe to do so. During a pandemic, this is no longer a valid simplification but incorporating these aspects into our models is a relatively new area that presents important methodological aspects, particularly regarding the modeling approach and resulting data requirements. Should we model at an even more macro level than normal or delve into the extreme detail of agent-based simulation? Is there a reasonable middle ground? This session will present work from experts that are taking on these challenges in the context of COVID-19.