Overview: Speakers will present the main criteria for critical appraisal of systematic reviews of cost and cost-effectiveness outcomes (SR-CCEOs) and introduce the ISPOR CrIteria for Cost (-Effectiveness) Review Outcomes (CiCERO) Checklist. CiCERO comprises the task force’s recommendations and 13 signaling questions to consider when evaluating the risk of bias in SR-CCEOs, as well as the quality of their conduct and reporting.

Purpose: There has been a significant increase in the number of SR-CCEOs. The differences in clinical and health settings, heterogeneity in applied methods, and reporting make it challenging to interpret the findings of SR-CCEOs. An analysis of guidelines on conducting and reporting SR-CCEOs resulted in the identification of multiple disagreements in these recommendations, hence the motivation behind the ISPOR Good Practices Task Force Report.

Recommendations are organized in six stages:

• planning and development
• search in SR-CCEOs
• study selection and eligibility
• critical appraisal of the included studies
• data extraction and synthesis
• presentation and reporting.

Description: This forum will give participants clear guidance and experience on using the 3 different CiCERO versions for reviews that:

• summarize cost and cost-effectiveness outcomes
• focus on methods of cost and cost-effectiveness studies
• use AMSTAR-2 as the main tool.

The forum will also facilitate discussion of the most controversial aspects of evaluation of quality and risk of bias in systematic reviews, such as obligatory components in SR-CCEOs’ aims, search restrictions and transferability, and approaches to synthesis in SR-CCEOs. It will include a hands-on training using the CiCERO checklist to appraise an example SR-CCEO. This presentation will benefit researchers, payers, assessors, regulators and health technology producers. Developed by the ISPOR Systematic Reviews with Cost- and Cost-effectiveness Outcomes Good Practices Task Force.