COVID-19 has brought the strengths and weaknesses of health systems around the world into sharp relief. We have seen health systems respond more quickly and more cohesively than many thought possible—new hospitals were built in record time, countries pulled together to create PPE stockpiles, and the spirit of collaboration in the pharmaceutical sector to bring a vaccine to market has been positive and encouraging. What have we learned about resilience, sustainability, and the ability to respond effectively during the crisis? And how can HEOR experts help build resilient healthcare systems, on both human and fiscal levels going forward? This session will consider what useful lessons we have learned from the SARS-CoV-2 pandemic so far, and what health systems need from the HEOR community to help build resilience and sustainability in healthcare systems.