HEALTHCARE RESOURCE UTILIZATION ASSOCIATED WITH GIANT CELL ARTERITIS IN THE UNITED STATES
Author(s)
Punekar R1, LaFontaine P2, Stone JH3
1Sanofi, Cambridge, MA, USA, 2Sanofi, Morristown, NJ, USA, 3Harvard Medical School, Boston, MA, USA
Presentation Documents
BACKGROUND: Giant cell arteritis (GCA) is a rare but potentially dangerous vascular disease. Prompt and long-term treatment with glucocorticoids is standard of care. Currently, there are limited data on the real-world healthcare burden of GCA. OBJECTIVES: To compare the healthcare resource utilization (HCRU) of GCA patients with the general population (GnP). METHODS: Data were from the Optum’s de-identified Clinformatics® Data Mart Database from 01/01/2006 to 06/30/2018 (study period). Patients with ≥1 inpatient or ≥2 outpatient claims (≥30 days apart) with GCA-related diagnosis codes between 01/01/2007–06/30/2017 (patient identification period) were included in the GCA cohort; the service date of first GCA medical claim was set as their index date. Patients without any medical claims for rheumatoid arthritis, polymyalgia rheumatica, or GCA during the study period were included in the GnP cohort; 12 months from the start of continuous health plan enrollment was set as their index date. Patients in both cohorts were required to be ≥50 years (on the index date) with ≥12 months continuous health plan enrollment before and after the index date. GCA and GnP cohorts were 1:1 propensity score-matched. Statistical analyses (t-test/Wilcoxon Sum Rank test, Chi-square/Fisher’s exact tests) compared HCRU between GCA and GnP cohorts. RESULTS: Among 6071 patients identified in each of the matched GCA/GnP cohorts, mean (SD) age was 74.5 (±8.3) years, mean (SD) Elixhauser comorbidity score was 3.4 (2.6), and the majority were female (73.9%). During 1-year follow-up period, proportions of patients with ≥1 hospitalizations (37.6% vs 20.4%), emergency room visits (52.2% vs 31.8%), physician visits (97.6% vs 90.9%), and rheumatologist visits (36.0% vs 2.3%) were significantly higher (P<0.0001) among GCA patients than the GnP cohort, respectively. CONCLUSIONS: GCA patients have significantly increased HCRU versus matched, highly comorbid patients from the general population.
Conference/Value in Health Info
2020-05, ISPOR 2020, Orlando, FL, USA
Value in Health, Volume 23, Issue 5, S1 (May 2020)
Code
PMS12
Topic
Economic Evaluation, Health Service Delivery & Process of Care
Topic Subcategory
Cost-comparison, Effectiveness, Utility, Benefit Analysis, Disease Management, Prescribing Behavior, Treatment Patterns and Guidelines
Disease
Musculoskeletal Disorders