This course will provide a basic understanding of the concepts of discretely-integrated condition event (DICE) simulation as it is applied in health technology assessment (HTA). Topics to be covered are: what is the basic idea of DICE; what are its components; how does it work; how is it conceptualized; how are outcomes obtained; how to implement a DICE in EXCEL (including both discrete event simulation and Markov models, and their combination in a single structure); how to do structural sensitivity analyses; what are the advantages and disadvantages of DICE. For this course, participants are required to bring a fully charged personal laptop equipped with Microsoft Excel installed, a version 2007 or later. It needs to be a Windows version so if it is on a Mac, a Windows emulator and Windows Excel is needed.