Background: There is an estimated 1.1 million people living with HIV in the United States, with a disproportionate impact of HIV diagnosed in the Southern region. The burden of HIV/AIDS is not evenly distributed among race and gender. In 2017, 37% of HIV infections in the Southern region were attributed to women, with 52% among African Americans, 23% among Whites and 21% among Hispanics. Southerners possess the highest incidence and death rates of HIV cases among any other geographic region in the U.S. Income inequality, transportation, poverty and limited access to healthcare resources are associated with poorer health outcomes in the Southern region. Objective: To measure socioeconomic status (SES) and incomplete virologic suppression to improve health outcomes for women living with HIV in the Southern region. The purpose of this research is to compare the SES measurements of women living with/without HIV in Florida to women living with/without HIV in New York, and to determine the association between SES and morbidity and mortality rates on health outcomes. Methodology: This study uses a qualitative approach, with a descriptive methodology to compare SES measurements of education, income and occupation, utilizing the Women Interagency HIV Study data consisting of treated HIV history in a cohort of HIV seropositive and seronegative women. Inclusion criteria consists of HIV seropositive and seronegative women, receiving clinical care at the New York City Consortium and Miami Florida clinical sites during 2013-2018. An inferential statistics t-test will be used to determine if there is a statistically significant difference in SES and incomplete virologic suppression between women in Florida and New York. Recommendations: Findings can assist policy makers and stakeholders by identifying SES effects at the societal level that lead to incomplete virologic suppression and death among other HIV-related issues that impact health outcomes for women in the Southern region.