OBJECTIVES: When conducting an SLR, clinical evidence is searched either as combination of both interventional and RWE, or separately. NICE requires combining all clinical evidence. Flexibility is needed in reporting interventional and RWE evidence separately to support indirect comparisons and other health-economic analyses for both. We explored whether a Living-SLR tool can significantly improve efficiency by accommodating both types of evidence and creating combined clinical evidence NICE submission tables.

METHODS: LiveSLR® is an up-to-date Cochrane/NICE-compliant curated SLR library following PRISMA standards, maintained by experienced reviewers. Interventional and RWE clinical evidence may be searched together or separately depending on the scientific question. We compared the time savings in preparing NICE submission clinical data tables containing both interventional and RWE evidence manually vs. using LiveSLR® automated reporting.

RESULTS: The relapsed/refractory multiple myeloma library in LiveSLR® was used, where interventional and RWE evidence were searched separately in 8 SLR updates. Six tables in each category were created: study characteristics (12 columns), patient characteristics (11 columns), Overall Survival and Progression-Free Survival summary (14 columns x 2), response summary (14 columns), safety (14 columns). On average, each table took approximately 4 hours to prepare manually, totaling 48 hours. LiveSLR® automatically combined interventional and RWE evidence, generating 12 tables in total within 1 minute, including a full Microsoft Word report detailing the methods and NICE-required appendices. LiveSLR® saved 47 hours and 59 minutes, which is 99.97% improvement in efficiency.

CONCLUSIONS: LiveSLR® library is an effective means to generate NICE submission tables for clinical evidence, allowing flexibility in searching interventional and RWE evidence separately.