Public Health Impact of Switching From a Trivalent to a Quadrivalent Inactivated Influenza Vaccine in Ecuador
Author(s)
Zerda I1, Gorecki M1, Clay E2, Garcia W3, Botero L3, Londono S3
1Creativ-Ceutical, Krakow, Poland, 2Creativ-Ceutical, Paris, France, 3Sanofi, Bogota, Colombia
Presentation Documents
OBJECTIVES: In 2006, Ecuador’s Ministry of Public Health implemented the seasonal influenza vaccination program with trivalent influenza vaccine (TIV) supplied free of charge through annual campaigns. This study aims to retrospectively estimate the comparative disease burden of influenza during seasons 2010 to 2019 with QIV-SD vaccination, over the actual adopted TIV scenario in Ecuador. METHODS: The number of influenza cases, general practice (GP) visits, hospitalizations, and deaths due to influenza, alongside the costs of treatment and workdays lost were compared in scenarios with TIV and QIV over nine influenza seasons. Public payer and societal perspectives were considered. Influenza incidence and complications rates were extracted from the literature and the Pan American Health Organisation database. The distribution of circulating influenza strains was derived from the PAHO database. Vaccine efficacy and coverage rates were based on clinical trials and national statistics, respectively. Modelling results were validated by local experts. Deterministic sensitivity analysis was explored. RESULTS: Although high-risk groups were vaccinated at a relatively high rate (77% in children aged <4 years, 69% in people aged ≥65 years, 81% among health workers, 52% among pregnant women and 94% among people with chronic diseases), besides its impact on productivity, each year the disease resulted in an average of 591,661 consultations, 8,943 hospitalizations and 688 deaths. Retrospectively, replacing TIV with QIV would have resulted in avoiding 42,325 influenza cases, 22,470 GP visits, 549 hospitalizations and 29 deaths due to influenza reported over the seasons 2010 to 2019. As a result, US$ 1,081,673 and US$ 2,251,705 would have been saved from public and societal perspectives, respectively. Sensitivity analysis confirmed these findings. CONCLUSIONS: Switching from TIV to QIV in the past influenza immunization campaigns in Ecuador would have prevented many illnesses and deaths caused by influenza and reduced health care resource use, leading to substantial savings.
Conference/Value in Health Info
2022-11, ISPOR Europe 2022, Vienna, Austria
Value in Health, Volume 25, Issue 12S (December 2022)
Code
EE174
Topic
Economic Evaluation, Epidemiology & Public Health
Topic Subcategory
Budget Impact Analysis, Public Health
Disease
No Additional Disease & Conditions/Specialized Treatment Areas