OBJECTIVES: Enzyme preparations are widely used for the treatment of gastroenterological diseases with indigestion. The aim of research - assessment of the volume and structure of consumption of enzyme preparations (group А09АА) in Ukraine in 2018-2020 and a comparison of their consumption in Ukraine with other countries (Norway and Estonia).

METHODS: Assessment of enzyme preparations consumption was carried out by ATC/DDD-methodology. International index of DDDs / 1000 inhabitants / day was calculated at carrying out research. Number of drugs packaging, which were sold for a year in Ukraine, was taken from the information system «Pharmexplorer» of Company «Morion». The drugs consumption level in Norway and Estonia was estimated using statistical data of these countries. A DDD of enzyme preparations are taken from the WHO website (https://www.whocc.no/). The prescribed daily dose (PDD) was calculated using the instructions for medical use in the absence of a DDD for the drug. The unit dose (number of tablets or capsules) was used instead of the DDD for combination products.

RESULTS: Consumption volumes of enzyme preparations in Ukraine were as follows: 2018 – 9.29; 2019 – 9.08; 2020 - 8.46. According to the consumption volumes of enzyme preparations in 2018-2020 countries studied can be positioned the following order: Ukraine > Estonia > Norway. During the 2018-2020, the volumes of enzyme preparations consumption decreased in Ukraine, increased - in Norway and Estonia. Drugs of the group A09AA02 «Multienzymes (lipase, protease etc.)» were presented in all the countries studied, drugs of the group A09A A10** «Other» – only in Ukraine.

CONCLUSIONS: Approximately from 0.85 to 0.93 % of the Ukraine population every day took 1 DDD of one of enzyme preparations in 2018-2020. Ukraine ranked first place in terms of consumption of enzyme preparations in this period among the countries studied.