Phase Angle, Quality of Life and Survival in Women With Head and Neck Cancer: An Uncommon Condition
Author(s)
González Rodríguez J1, Sat-Muñoz D2, Martínez-Herrera B3, Gutiérrez-Rodríguez LX4, Mireles-Ramírez M5, Trujillo-Hernández B6, Quiroga-Morales LA7, Alcaráz-Wong AA8, Dávalos-Cobian C8, Solórzano-Meléndez A9, Flores-Carlos JD10, Rubio Jurado B9, Salazar-Páramo M11, Gómez-Sánchez E12, Carrillo-Nuñez GG11, Nava-Zavala AH13, Balderas-Peña LMA14
1Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Zapopan, JAL, Mexico, 2Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, JAL, Mexico, 3Hospital General de Zona No. 2 "Dr. Francisco Padrón Puyou", Colima, Mexico, 4Universidad de Guadalajara. Centro Universitario del Sur, Ciudad Guzmán, JA, Mexico, 5Instituto Mexicano del Seguro Social. UMAE Hospital de Especialidades. Centro Médico Nacional de Occidente, Guadalajara , JAL, Mexico, 6Universidad de Colima, Colima, JA, Mexico, 7Universidad Autónoma de Guadalajara, Zapopan, JA, Mexico, 8Instituto Mexicano del Seguro Social. UMAE Hospital de Especialidades. Centro Médico Nacional de Occidente, Guadalajara, JA, Mexico, 9UMAE Hospital de Especialidades Centro Médico Nacional de Occidente IMSS, Guadalajara, Jalisco, JA, Mexico, 10UMAE Hospital de Especialidades Centro Médico Nacional de Occidente., Guadalajara, Jalisco, JA, Mexico, 11Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, JA, Mexico, 12Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico, 13Instituto Mexicano del Seguro Social, Órgano de Operación Administrativa Desconcentrada Jalisco, Guadalajara, JA, Mexico, 14Universidad de Guadalajara. Centro Universitario de Ciencias de la Salud, Guadalajara, JAL, Mexico
Presentation Documents
OBJECTIVES: To determine the role of phase angle in survival and QoL in a women population with H&N cancer
METHODS: The selected subjects were divided into two groups: women with PA < 4.30° and women with PA ≥ 4.30°. Both of them were followed up for at least two years. We used EORTC QLQ-C30 and H&N35 to evaluate QoL, and Kaplan-Meier to analyze survival rate.
RESULTS: The sample studied consisted of 32 patients with a mean age of 57.6 years. Patients with a PA ≥ 4.30 had an ≈50% higher probability of survival at two years with a better quality of life compared to patients with a PA< 4.47°. Statistical differences were found in the functional and symptom scales, with lower functional scores and higher symptom scores in patients with low PA. In QLQ-C30 the observed differences were Global Health State/QoL (mean 70.8 versus 75; p=0.254), physical (66.7 versus 84.4, p=0.05) and role (71.7 versus 76.4, p=0.711) functioning, and loss of appetite (43.3 versus 16.7; p=0.029), in QLQ H&N35: senses problems (33.2 versus 5.6; p=0.007), speech problems (41.1 versus 16.7; p=0.047), Teeth (56 versus 25; p=0.036), sticky saliva (52.1 versus 19.4, p=0.017). Median survival was 16.7 months for those with PA <4.3° versus 32.7 months for those with PA ≥ 4.3° (p<0.026). The percentage of deceased subjects 75% versus 33.3%; p=0.041).
CONCLUSIONS: Even with an extremely low number of female patients with non-thyroid H&N cancer, phase angle lower than 4.3º was the most crucial predictor of impaired QoL, worse survival and a risk factor for death.
Conference/Value in Health Info
Value in Health, Volume 25, Issue 12S (December 2022)
Code
CO34
Topic
Clinical Outcomes, Patient-Centered Research
Topic Subcategory
Patient-reported Outcomes & Quality of Life Outcomes, Relating Intermediate to Long-term Outcomes
Disease
SDC: Musculoskeletal Disorders (Arthritis, Bone Disorders, Osteoporosis, Other Musculoskeletal), SDC: Oncology, STA: Nutrition