Hypertension As a Prognostic Factor in the Prediction of Mortality in Patients with COVID-19: A Systematic Review and Meta-Analysis
Author(s)
ABSTRACT WITHDRAWN
OBJECTIVES to determine the predictive value of hypertension as a comorbidity in COVID-19 mortality. METHODS Participants included all patients clinically diagnosed with COVID-19, and have hypertension as their pre-existing medical condition. Studies were selected based on study design, participants, exposure, outcome, timing, setting and language. The following databases were searched from June to August 2020 for case control and cohort studies on MEDLINE and CINAHL, ScienceDirect, Clinical Key, OVID database, Wiley Online library, and UpToDate. The criteria for evaluation of risk of bias were based on the selection bias, comparability bias and outcome bias. All information gathered were collated and evaluated using the Newcastle-Ottawa Quality Assessment Scale and CEBM. RESULTS Individual studies all showed a significant relationship between hypertension and mortality in COVID-19 patients. Odds ratio ranging from 1.75 to 28.88, and hazard ratio ranging from 1.49 to 3.32 are present in the studies. For the data analysis, Mantel Haenszel method and random effects model was used for case control studies with odds ratio as effect measure; while Inverse variance method and fixed model was used for cohort studies with hazard ratio as effect measure. Both groups showed significant positive association between mortality and hypertension as a prognostic factor. Overall odds ratio is 5.25 (2.42-11.40) with a p value of < 0.00001, and the pooled hazard ratio is 2.21(1.75-2.80) with a p value of < 0.00001. This shows that there is an increased risk of mortality among COVID-19 patients with hypertension as a comorbid condition. CONCLUSIONS Hypertension as a comorbid condition is a prognostic factor in the prediction of mortality in hospitalized COVID-19 patients. The ten included studies showed that there is a significant positive association suggesting an increased risk of mortality in COVID-19 patients with hypertension.
Conference/Value in Health Info
2021-11, ISPOR Europe 2021, Copenhagen, Denmark
Value in Health, Volume 24, Issue 12, S2 (December 2021)
Code
POSC174
Topic
Clinical Outcomes, Epidemiology & Public Health
Topic Subcategory
Clinical Outcomes Assessment, Clinician Reported Outcomes, Public Health
Disease
Cardiovascular Disorders, Infectious Disease (non-vaccine)