Managed Entry Agreements, Coverage with Evidence Development and Multi-Criteria Decision Analysis are tools for assessing mainly the highly innovative health technologies from more holistic and objective perspectives, including social impact, ethical and organizational dimensions and other issues, critical for proper evaluation of the innovation and its value for patients, caregivers, healthcare professionals, payers and society. Limited examples of utilizing those tools and methods are already available in CEE region and further research is needed in order to apply them correctly within the context of CEE region healthcare settings, taking into considerations usually limited capacities and capabilities of stakeholders engaged in a process of assessment and appraisal.