The Search for the Cure: Analysis of Ongoing Clinical Trials of Treatments for COVID-19 Patients
Author(s)
ABSTRACT WITHDRAWN
OBJECTIVES: SARS-CoV-2 infections have severely affected all nations, with high mortality rates and limited understanding of effective treatments. As a result, while vaccines are being developed, multiple clinical trials have been initiated with the goal of developing successful clinical therapies to treat patients affected with the virus. This study is designed to provide a clear, up-to-date and accurate landscape analysis of all ongoing clinical trials. METHODS: All interventional studies in clinicaltrials.gov evaluating patients with SARS-CoV-2 infections starting Jan,2020 were analyzed. Findings reported herein are as per June 30th, however this study is ongoing and analyses are rerun on a continuous basis. Studies were categorized based on intervention type (drug vs biologic vs other intervention), drug type, study phase, study duration and location. Natural language processing methods were developed to further sub-categorize studies based on keywords. RESULTS: A total of 1,104 distinct clinical trials, recruiting for 1,931,386 patients were identified; 939 studies ongoing, 47 completed, 34 were suspended or terminated or withdrawn, 53 active studies not recruiting and 31 enrolling by invitation. Of the 939 ongoing studies, 68.05% were phase 1-4, with 519 drug trials and 116 biological trials. The drug trials were dominated by hydroxychloroquine and combination of hydroxychloroquine with other drugs (N=102), convalescent plasma (N=15), steroid trials (methylprednisolone: N= 8) and Tocilizumab (N=5). 28.65% studies identified a completion date prior to November 1st, and trial durations averaged 343 days with 262 trial with duration of less than 181 days; Main ongoing trial locations were US (243), France (95), Spain (44) and China (41). CONCLUSIONS: The clinical and economic gravity of the SARS-CoV-2 pandemic has resulted in a large number of clinical trials. Continuous analysis of ongoing trials and outcomes is critical to ensure coordinated efforts to maximize research effectiveness. This systematic review of ongoing trials provides a real-time assessment of key treatments.
Conference/Value in Health Info
2020-11, ISPOR Europe 2020, Milan, Italy
Value in Health, Volume 23, Issue S2 (December 2020)
Code
PIN93
Topic
Epidemiology & Public Health
Topic Subcategory
Public Health
Disease
Infectious Disease (non-vaccine)