Characterization of the Clinical Pathway and Treatment Patterns for Post-Myocardial Infarction Patients: A Physician Survey

Author(s)

Qureshi N1, Antoniou S2, Cornel JH3, Schiele F4, Perrone-Filardi P5, Brachmann J6, Sidelnikov E7, Villa G7, Ferguson S8, Rowlands C9, Gonzalez-Juanatey JR10
1University of Nottingham, Nottingham, UK, 2Barts Health NHS Trust, London, UK, 3Radboud University Medical Center, Nijmegen, Netherlands, 4Regional University Hospital Jean Minjoz, Besancon, France, 5Federico II University Hospital, Naples, Italy, 6Regiomed-Kliniken, Coburg, Germany, 7Amgen (Europe) GmbH, Rotkreuz, Switzerland, 8PRMA Consulting, Fleet, UK, 9PRMA Consulting, Bordon, Great Britain, 10Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain

OBJECTIVES: Describe lipid-lowering therapy (LLT) treatment patterns in post-MI patients and adherence to 2019 ESC/EAS dyslipidemias guidelines.

METHODS: A cross-sectional survey was conducted in France, Germany, Italy, Netherlands, Spain, and United Kingdom (UK). A stratified sample of 60 physicians (cardiologists and general practitioners [GPs]) were surveyed in each country.

RESULTS: Of 360 physicians surveyed, 233 (64.7%) were secondary care cardiologists and 127 (35.3%) were primary care physicians (PCPs). 13.5% of cardiologists and 18.9% of PCPs reviewed LLT for all patients within 12 weeks of discharge after MI. 82.0% of cardiologists and 55.1% of PCPs stated that they consulted ESC/EAS guidelines, 42.9% of cardiologists and 55.1% of PCPs consulted national guidelines. Most physicians (86.9%) used LDL-C to assess lipid profile. Total cholesterol was mostly used in the UK, where 80.0% of GPs used that measure. For patients not achieving recommended lipid levels at 12 weeks, 90.6% of cardiologists would change LLT regimen immediately, 7.6% would wait longer, and 1.8% would take no action. Among PCPs, 51.6% would change LLT regimen immediately, 47.6% would wait longer, and 0.8% would take no action. Evaluating fictitious cases of post-MI patients whose LDL-C target recommended by ESC/EAS guidelines could not be reached using statins and ezetimibe, 23.0% of cardiologists and 6.3% of PCPs indicated that they would prescribe PCSK9 inhibitors.

CONCLUSIONS: Less than one fifth of physicians follow the recommendations of ESC/EAS guidelines and review all post-MI patients in their care within 12 weeks of discharge. When LDL-C goals are not reached, almost all cardiologists and approximately half of PCPs would change LLT. A small proportion of physicians use intensive LLT with PCSK9 inhibitors for post-MI patients, as recommended by ESC/EAS guidelines. These data suggest that education of physicians treating MI patients may be warranted.

Conference/Value in Health Info

2020-11, ISPOR Europe 2020, Milan, Italy

Value in Health, Volume 23, Issue S2 (December 2020)

Code

PCV80

Topic

Health Service Delivery & Process of Care

Topic Subcategory

Disease Management, Treatment Patterns and Guidelines

Disease

Cardiovascular Disorders

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