INDIRECT COSTS ASSOCIATED WITH SKIN AND SOFT TISSUE INFECTIONS IN CHILDREN- A SYSTEMATIC LITERATURE REVIEW
Author(s)
Lizano-Díez I, Naharro J, Zsolt I
Ferrer, Barcelona, Spain
Presentation Documents
OBJECTIVES: A systematic literature review (SLR) was conducted to identify the evidence reported in the literature about indirect costs associated with skin and soft tissue infections (SSTIs) in children worldwide. METHODS: The SLR was conducted through PubMed database in March 2019. Thirteen search strategies were designed combining MeSH vocabulary and free terms. SSTIs were defined as bacterial, viral, dermatomycoses and parasitic infestations. Only primary studies and reviews were included. No time or language limit was determined. The identified studies were peer-reviewed to assess their inclusion. RESULTS: All search strategies resulted in 493 references; 174 after duplicates removal. Inclusion criteria application resulted in 17 studies for analysis. In case of bacterial SSTIs, schooldays lost due to impetigo varied from 1.2 to 6.5. Working parents and school-age children were less likely to alter their daily activities in case of taking topic antibiotic (p<0.04). Besides, the estimated productivity losses related to community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in children <15 years old were US$6,806 (2011 US$), based on impetigo, cellulitis and folliculitis. For varicella, the lost work by caregivers was estimated for outpatient and inpatient children from 1 to 12 years old. Results were €190.8 and €238.9 (Poland), €108.4 and €182 (Hungary), US$207 and US$143.2 (Argentina) respectively (2015 currency). In case of parasitic infestations, the estimated proportion of children that missed school in Australia as a result of pediculosis was high (up to 30%). The related parental wages lost were estimated as 20 days of work in the US (US$2,720; 2003 US$). CONCLUSIONS: The economic burden of SSTIs is highly relevant but underestimated due to the lack of studies, especially for bacterial SSTIs. Quantifying SSTIs burden could help motivate, plan for and guide investment of decision makers in relevant interventions to reduce transmission and infection incidence, as well as early identification and appropriate treatment before they progress.
Conference/Value in Health Info
2019-11, ISPOR Europe 2019, Copenhagen, Denmark
Code
PIN99
Disease
Infectious Disease (non-vaccine), Pediatrics