OBJECTIVES

Health-state utility values are critical input and key drivers for most cost-utility analysis. This study evaluates how the utility values have been modeled in cost-utility studies conducted from an Indian perspective.

METHODS

PubMed, National Health Service Economic Evaluation Database (NHSEED) and Cochrane library databases were systematically searched to identify cost-utility studies, conducted from an Indian perspective, published from November 2009 to November 2019. In addition, hand searching was also conducted. Two researchers independently reviewed and assessed the quality of the studies using Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Discrepancies between the two reviewers were solved by discussion with the third reviewer.

RESULTS

Out of 2077 articles, 35 studies were the cost-utility studies. Eighteen studies retrieved the utility values from the published literature, 13 used different utility instruments and four collected utility values via interviews Two studies used EQ-5D-5L, one used EQ-5D-3L whereas three additional studies which used EQ-5D did not report the details about level. Three studies used WHODAS 2.0 and one study used WHODAS II. In addition, one study each used SF-12, SF-36, VF-14 and CIS-R (one study used both CIS-R and WHODAS 2.0). Excluding death, the utility values of the therapeutic areas most often modelled like infectious diseases, ophthalmology, endocrine disorders and oncology, ranged from 0-1, 0.18-0.99, 0.55-0.87 and 0.5-0.94, respectively. For the rest of the therapeutic areas, such as blood disorders, mental disorders, nephrology and neurology, utility values ranged from 0.61-0.93, 0.82-0.84, 0.39-0.71 and -0.495-0.9, respectively.

CONCLUSIONS

This systematic review provides a set of published health state utility values of different therapeutic areas modelled in cost utility evaluations conducted from Indian perspective. It also provides an overview of the methods and the instruments employed to retrieve the utility values