Presentation (CTI)

OBJECTIVES: To validate a web-based approach for estimating the impact of intervention price changes on cost-effectiveness model outputs.
METHODS: Three published cost-effectiveness analyses with associated open-source models were selected for validation. For each model, intervention acquisition costs were separated from other modelled costs and outcomes. The intervention price was then varied across the published base case and six alternative pricing scenarios. The same price changes were applied both in the original open-source economic models and in the application. Predicted outputs from the application were compared with the corresponding outputs generated by the full economic models.
RESULTS: The validation case studies were selected from different disease areas: chronic pain, infectious disease, and lung cancer. This ensured that the validation exercise was broad and not specific to one type of cost-effectiveness analysis. Across the three validation cases, the published base-case and six alternative intervention price scenarios were tested. The application reproduced the expected direction of incremental cost-effectiveness ratio (ICER) change as intervention prices varied. Without changing the underlying assumptions of the cost-effectiveness analyses, the approach was used to assess the impact of changes in intervention price, cost-effectiveness threshold, and comparator price. The application showed 100% agreement with base-case prices across all models and directional agreement with the full-model outputs across all scenarios. Results were consistent with the outputs generated by the corresponding open-source models, supporting the approach to approximate price-driven changes and cost-effectiveness outcomes without requiring repeated full model runs. This enabled rapid comparison across scenarios while preserving a clear link to the original cost-effectiveness assumptions and published evidence base.
CONCLUSIONS: The validation demonstrated that the approach could reproduce price-driven changes in ICERs across selected published cost-effectiveness models, while remaining grounded in the structure and assumptions of the source economic models.