PREVALENCE OF DISORDERS OF GUT-BRAIN INTERACTION (DGBIS) AND THE IMPACT OF COMORBID FOOD HYPERSENSITIVITY ON HEALTHCARE-SEEKING BEHAVIOUR: A CROSS-SECTIONAL ANALYSIS
Author(s)
Ranjit Rajesh Jaid, Pharm D1, Payal Vilas Jadhav, Pharm D2, Prasad Ashtankar, Pharm D2, Prajakta Tapkir, Pharm D2, Anjana Barola, PhD3, Komal Deosarkar, Pharm D2, Dr. Amol Dahale, MBBS, MD4.
1Student, Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India, 2Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India, 3Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, Pune, India, 4Dr. D.Y. Patil Medical College Hospital and Research Centre,Pune, Pune, India.
1Student, Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India, 2Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, India, 3Dr. D.Y. Patil Dnyan Prasad University's School of Pharmacy and Research, Pune, Pune, Pune, India, 4Dr. D.Y. Patil Medical College Hospital and Research Centre,Pune, Pune, India.
OBJECTIVES: To evaluate the prevalence of disorders of gut-brain interaction (DGBIs) in individuals with or without self-reported food hypersensitivity and their healthcare-seeking behaviour.
METHODS: A cross-sectional study was conducted among 2,000 adults aged 18-65 years. Disorders of gut-brain interaction (DGBIs) were identified using the validated Rome IV Diagnostic Questionnaire for Adults, and self-reported food hypersensitivity (FHS) was confirmed through symptom reporting followed by a food re-challenge. Chi-square tests and odds ratios (ORs) with 95% confidence intervals (CIs) were used to identify DGBI subtypes significantly associated with FHS. A nominal logistic regression model was applied to evaluate the influence of comorbid FHS and DGBIs on healthcare-seeking behaviour.
RESULTS: The overall DGBI prevalence was 29.8%, and was significantly higher with self-reported food hypersensitivity (FHS) than without (34.67% vs. 28.77%; OR=1.31, 95% CI: 1.03-1.68; p=0.0286). Significant subtype associations were found for Functional Dyspepsia (13.31% vs. 8.48%; OR=1.66, 95% CI: 1.10-2.49; p=0.0193) and Irritable Bowel Syndrome (6.94% vs. 3.21%; OR=2.25, 95% CI: 1.26-4.88; p=0.0104). The presence of comorbid FHS and Functional Dyspepsia (FD) increased healthcare-seeking odds nearly sevenfold (OR=6.84, 95% CI: 2.55-18.38; p=0.0001), while comorbid FHS and IBS increased odds over fourfold (OR=4.68, 95% CI: 1.13-19.38; p=0.0333).
CONCLUSIONS: Self-reported food hypersensitivity was associated with a higher prevalence of DGBIs, particularly irritable bowel syndrome and functional dyspepsia. Comorbid FHS and DGBIs substantially increased healthcare-seeking behaviour, indicating a greater healthcare burden. These findings support routine assessment of food hypersensitivity in patients with FD and IBS to improve clinical management and inform healthcare resource planning.
METHODS: A cross-sectional study was conducted among 2,000 adults aged 18-65 years. Disorders of gut-brain interaction (DGBIs) were identified using the validated Rome IV Diagnostic Questionnaire for Adults, and self-reported food hypersensitivity (FHS) was confirmed through symptom reporting followed by a food re-challenge. Chi-square tests and odds ratios (ORs) with 95% confidence intervals (CIs) were used to identify DGBI subtypes significantly associated with FHS. A nominal logistic regression model was applied to evaluate the influence of comorbid FHS and DGBIs on healthcare-seeking behaviour.
RESULTS: The overall DGBI prevalence was 29.8%, and was significantly higher with self-reported food hypersensitivity (FHS) than without (34.67% vs. 28.77%; OR=1.31, 95% CI: 1.03-1.68; p=0.0286). Significant subtype associations were found for Functional Dyspepsia (13.31% vs. 8.48%; OR=1.66, 95% CI: 1.10-2.49; p=0.0193) and Irritable Bowel Syndrome (6.94% vs. 3.21%; OR=2.25, 95% CI: 1.26-4.88; p=0.0104). The presence of comorbid FHS and Functional Dyspepsia (FD) increased healthcare-seeking odds nearly sevenfold (OR=6.84, 95% CI: 2.55-18.38; p=0.0001), while comorbid FHS and IBS increased odds over fourfold (OR=4.68, 95% CI: 1.13-19.38; p=0.0333).
CONCLUSIONS: Self-reported food hypersensitivity was associated with a higher prevalence of DGBIs, particularly irritable bowel syndrome and functional dyspepsia. Comorbid FHS and DGBIs substantially increased healthcare-seeking behaviour, indicating a greater healthcare burden. These findings support routine assessment of food hypersensitivity in patients with FD and IBS to improve clinical management and inform healthcare resource planning.
Conference/Value in Health Info
2026-11, ISPOR Europe 2026, Vienna, Austria
Value in Health, Volume 29, Issue 12S
Code
EPH169
Topic
Clinical Outcomes, Epidemiology & Public Health
Disease
Gastrointestinal Disorders